We are interested in advancing biomedical science by developing technologies that redefine the boundaries of discovery. We develop next-generation antibodies with unmatched precision to diagnose and treat disease. Leveraging AI, proteomics and protein engineering, we aim to uncover novel biology and accelerate drug discovery. Our lab is dedicated to fostering a collaborative and inclusive environment where curiosity, creativity, and scientific rigor drive groundbreaking advancements.
Research Statement
05/08/26: Our MINDS paper has been accepted at Nature Communications. MINDS is a modular nanobody platform that co-targets multiple cancer receptors to drive tumor-selective receptor degradation, and delivery of diverse therapeutic payloads including cytotoxic compounds, PROTACTs and molecular glues. Congrats Jeff, Md, Yufei and Paul! Beautiful paper! 🎉🎉🎉
05/01/26: Congrats to Jeff and the team. Our anti-staph toxin study has been accepted at Nature Communications- lovely work! 🎉🎉🎉
04/24/26: Congrats Zhe and Yufei on the Science Advances paper! 🎉🎉🎉
This exciting work introduces AF3-TurboAb- an AI-enabled pipeline for rapid, accurate and high-throughout antibody and nanobody structural prediction. It makes an important step in our efforts to connect AI prediction with high-quality therapeutic antibody design.
03/01/26: Excited that Frank has accepted a PhD offer from Mount Sinai, and that Zhe has received the Outstanding Research Award in Pharmacological Sciences! What an incredible journey, with so much more ahead! 🎉🎉🎉
11/27/25: Congrats Yufei on the Science paper with Marty Taylor at Brown University! Lovely work showing how mTORC2 recognizes its substrates.
11/25/25: Huge congrats on Frank and Zhe's Cell Systems paper! A beautifully crafted and significant computational biology study that reveals near-universal immune escape by SARS-CoV-2 antibodies and the extraordinary challenges of mitigating viral escape. Best wishes Frank on your PhD applications!
09/01/25: Celebrating our two amazing high school gals, Alba and Willa, for their lovely summer internship. STEM way to go!!!!!!
07/25/25: Successful thesis defense by Zhe! Huge congrats to Dr. Sang on receiving the Doctor of Distinction, adding another remarkable accolade to the group!🎉🎉🎉
06/13/25: Successful thesis defense by Jeff! Hats off to Dr. Kim on earning the Doctor of Distinction honor from Mount Sinai! Best wishes Jeff on your residency at Pitt! 🎉🎉🎉
10/23/24: Our AMETA technology is now published at Cell. Congratulations Yufei, Zhe and Pham! What an incredible journey!!! 🎉🎉🎉
10/01/2024: Congratulations, Paul, on receiving the NIH T32 Postdoctoral Fellowship! 🎉
Huge thank you to our supports!
